CE · ISO 13485 · GMP · Class III

ORTHOFLEX therapy
via intra-articular injection

Class III orthopedic medical devices, produced through biofermentation, CE and ISO 13485 certified. Innovative solutions for joints and tendons.

CE CE Marked
ISO 13485
GMP Certified
III Class III
About Us

Innovation in
Orthopedic Medicine

ORTOBRAND INTERNATIONAL is a Romanian multinational company focused on the research, development, production, marketing and sale of innovative hyaluronic acid (HA)-based orthopedic medical devices.

GMP-accredited by NSAI to European standards, with CE and ISO 13485 certifications for Class III medical devices.

CE Marked
ISO 13485
GMP Certified
Class III
💧

Viscosupplementation

Restoring the natural lubrication of the joints by supplementing or replacing the synovial fluid with hyaluronic acid — reducing friction, easing pain and improving mobility.

🔬

Biofermentation Technology

All HA is produced through biofermentation — eliminating sources of animal origin and any risk of allergic reactions. The autoclave sterilization process guarantees maximum safety.

🌍

Global Reach

Partnerships with specialized companies around the world to bring innovative orthopedic solutions to more patients in Europe and beyond.

Our Products

The ORTHOFLEX Product Line®

Four targeted solutions for joints and tendons — all in pre-filled, single-dose syringes.

ORTHOFLEX forte
View Product →

ORTHOFLEX forte

Cartilage protection & joint mobility

Hyaluronic acid 30mg/2ml. Intra-articular injection for the treatment of osteoarthritis (grade 1 and 2) and cartilage protection — 1–3 injections,…

Details
The Science Behind It

Why Hyaluronic Acid?

Natural HA decreases significantly in joints affected by osteoarthritis, causing pain, stiffness and cartilage deterioration.

ORTHOFLEX® products replace or supplement natural HA with high-purity hyaluronic acid, produced through biofermentation — free of animal sources, with no allergy risk.

A molecular weight of 3 MilDa for maximum efficacy, autoclave-sterilized, with a 2-year shelf life.

80%
of people over 55 are affected by osteoarthritis
33–50%
reduction of natural HA in arthritic joints
3 MilDa
high molecular weight for maximum efficacy
2 years
shelf life — autoclave-sterilized
Testimonials

Trusted by Specialists and Patients

See All Reviews →
★★★★★

"I have been prescribing ORTHOFLEX one to my patients for over two years. The single-injection protocol is revolutionary — patients appreciate not having to return for multiple visits."

MI
Dr. Mihai Ionescu
Orthopedic Surgeon, Bucharest
★★★★★

"After years of knee pain, my doctor recommended ORTHOFLEX forte. Two weeks after finishing the 3 injections I noticed a significant reduction in pain. I can walk much longer distances now."

EP
Elena Popa
Patient, 62 years old
★★★★★

"I regularly use ORTHOFLEX products for my athlete patients. The biofermentation origin means zero allergic reactions — I have not had a single adverse event."

CF
Dr. Cristian Florescu
Sports Medicine Doctor, Timișoara
Contact Us

Get in Touch

We are available for questions about products, orders or partnerships. We respond within 24 hours.

Address Strada Eroilor Nr. 1A, Otopeni, Ilfov, Romania

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